Katrin Anne Becker Selected Research

Amitriptyline (Elavil)

1/2021	Ex vivo assay to evaluate the efficacy of drugs targeting sphingolipids in preventing SARS-CoV-2 infection of nasal epithelial cells.
11/2020	Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells.
12/2019	Acid Sphingomyelinase Deficiency Ameliorates Farber Disease.
6/2015	Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis.
1/2014	Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons.
12/2010	Accumulation of ceramide in the trachea and intestine of cystic fibrosis mice causes inflammation and cell death.
6/2010	Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis.

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Katrin Anne Becker Research Topics

Disease

27	Infections 01/2021 - 01/2008
20	Cystic Fibrosis (Mucoviscidosis) 01/2021 - 11/2008
10	Neoplasms (Cancer) 10/2017 - 01/2008
9	Inflammation (Inflammations) 01/2019 - 06/2010
8	Pneumonia (Pneumonitis) 01/2019 - 01/2010
7	Bacterial Infections (Bacterial Infection) 11/2020 - 01/2008
4	COVID-19 12/2021 - 11/2020
4	Neoplasm Metastasis (Metastasis) 02/2021 - 06/2015
4	Pseudomonas Infections 01/2021 - 01/2010
3	Virus Diseases (Viral Diseases) 05/2021 - 11/2020
3	Vesicular Stomatitis 01/2021 - 11/2020
3	Melanoma (Melanoma, Malignant) 01/2017 - 06/2015
3	Sepsis (Septicemia) 06/2015 - 01/2008
2	Mood Disorders (Mood Disorder) 01/2022 - 06/2014
2	Farber Lipogranulomatosis 12/2019 - 01/2018
2	Multiple Sclerosis 01/2019 - 01/2017
2	Edema (Dropsy) 01/2018 - 06/2015
2	Glioblastoma (Glioblastoma Multiforme) 01/2017 - 01/2013
2	Glioma (Gliomas) 01/2017 - 01/2013
1	Brain Neoplasms (Brain Tumor) 02/2021
1	Asthma (Bronchial Asthma) 01/2020
1	Ventilator-Associated Pneumonia 01/2019
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2019
1	Acute Lung Injury 01/2018
1	Chronic Obstructive Pulmonary Disease (COPD) 01/2018
1	Rheumatoid Arthritis 01/2017
1	Arthritis (Polyarthritis) 01/2017
1	Central Nervous System Infections (Central Nervous System Infection) 10/2016
1	Staphylococcal Infections 01/2016
1	Lymphoma (Lymphomas) 07/2015
1	Leukemia 07/2015
1	Pulmonary Edema 06/2015
1	Bacteremia 06/2015
1	Pneumococcal Pneumonia 01/2015
1	Medically Unexplained Symptoms 06/2014
1	Neuralgia (Stump Neuralgia) 01/2014
1	Alzheimer Disease (Alzheimer's Disease) 01/2014

Drug/Important Bio-Agent (IBA)

34	CeramidesIBA 12/2021 - 01/2008
20	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 12/2021 - 11/2008
19	AcidsIBA 12/2021 - 11/2008
14	SphingosineIBA 01/2021 - 09/2014
7	SphingolipidsIBA 05/2021 - 01/2010
7	Amitriptyline (Elavil)FDA LinkGeneric 01/2021 - 06/2010
5	Acid CeramidaseIBA 01/2021 - 09/2014
5	CytokinesIBA 01/2020 - 11/2008
4	Antidepressive Agents (Antidepressants)IBA 01/2022 - 11/2020
4	LipidsIBA 01/2015 - 12/2010
4	Death Domain ReceptorsIBA 08/2011 - 01/2008
3	Phenobarbital (Luminal)FDA Link 01/2021 - 09/2014
3	SARS-CoV-2 spike proteinIBA 01/2021 - 11/2020
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2018 - 01/2015
3	Potassium Channels (Potassium Channel)IBA 10/2017 - 07/2015
3	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 09/2012 - 03/2010
2	Pharmaceutical PreparationsIBA 01/2021 - 11/2020
2	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 01/2021 - 01/2014
2	Sertraline (Zoloft)FDA LinkGeneric 11/2020 - 06/2010
2	Fluoxetine (Prozac)FDA LinkGeneric 11/2020 - 06/2010
2	EnzymesIBA 11/2020 - 01/2013
2	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 03/2010
2	Ion Channels (Ion Channel)IBA 10/2017 - 01/2010
2	LigandsIBA 06/2017 - 01/2010
2	Kv1.3 Potassium ChannelIBA 01/2017 - 07/2015
2	p38 Mitogen-Activated Protein KinasesIBA 01/2017 - 01/2016
2	IntegrinsIBA 01/2016 - 06/2015
2	Proteins (Proteins, Gene)FDA Link 07/2015 - 12/2010
1	alpha-galactosylceramideIBA 05/2021
1	NucleotidesIBA 02/2021
1	CyclohexanolsIBA 01/2021
1	Expectorants (Mucolytics)IBA 01/2021
1	Small Interfering RNA (siRNA)IBA 01/2021
1	Ambroxol (Mucosolvan)IBA 01/2021
1	interferon regulatory factor-8 (interferon consensus sequence binding protein)IBA 01/2021
1	Escitalopram FDA Link 11/2020
1	Imipramine (Janimine)FDA LinkGeneric 11/2020
1	Maprotiline (Ludiomil)FDA Link 11/2020
1	Saline SolutionIBA 11/2020
1	OvalbuminIBA 01/2020
1	PlasticsIBA 01/2019
1	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2019
1	arginyl-glycyl-aspartic acidIBA 06/2017
1	AntibodiesIBA 06/2017
1	Clofazimine (Lamprene)FDA Link 01/2017
1	Glucosylceramides (Glucocerebrosides)IBA 01/2017
1	5-(4-phenylbutoxy)psoralenIBA 01/2017
1	P-SelectinIBA 01/2017
1	AntigensIBA 01/2017
1	Biological ProductsIBA 10/2016
1	ezrinIBA 01/2016
1	Phospholipases (Phospholipase)IBA 01/2016
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2016
1	Superoxides (Superoxide)IBA 06/2015
1	Tight Junction ProteinsIBA 06/2015
1	Liposomes (Liposome)IBA 01/2015
1	ExotoxinsIBA 01/2015
1	Bacterial ToxinsIBA 01/2015
1	Fingolimod Hydrochloride (FTY720)FDA Link 09/2014

Therapy/Procedure

3	Therapeutics 01/2017 - 01/2013
2	Intravenous Injections 01/2017 - 06/2015
2	Drug Therapy (Chemotherapy) 07/2015 - 01/2013
1	Replacement Arthroplasty 01/2020